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OBJECTIVE@#To observe the effect of standardized Jin's three-needle therapy on limb motor function and nerve function defect in stroke patients, and to evaluate the placebo control method.@*METHODS@#A total of 66 patients with stroke were randomly divided into a Jin's three-needle group (33 cases, 3 cases dropped off) and a placebo needle group (33 cases, 4 cases dropped off). All the patients were treated with conventional medication and rehabilitation treatment. In addition, the patients in the Jin's three-needle group were treated with standardized Jin's three-needle therapy at temporal three points, spirit four points, hand three points, foot three points, upper extremity spasm three points, lower extremity spasm three points, etc.; while the patients in the placebo needle group were treated with placebo needling at identical points. All the treatments were given once a day, 5 days a week, and 3-week treatment was given with an interval of 2 days between weeks. The scores of Fugl-Meyer assessment scale (FMA) and National Institutes of Health stroke scale (NIHSS) were observed before treatment, 10 d and 21 d into treatment, and the blind evaluation was conducted after treatment.@*RESULTS@#On the 10 d and 21 d into treatment, the FMA scores in both groups were higher than those before treatment (P<0.01), and the NIHSS scores were lower than those before treatment (P<0.01). On the 10 d and 21 d into treatment, the FMA scores in the Jin's three-needle group were higher than those in the placebo needle group (P<0.05); on the 10 d into treatment, the NIHSS score in the Jin's three-needle group was were lower than that in the placebo needle group (P<0.05). There was no significant difference between the two groups on judging the type of treatment (P>0.05), and the consistency with the real situation was poor (Cohen's kappa coefficient<0.20).@*CONCLUSION@#The standardized Jin's three-needle therapy could effectively improve the limb motor function and nerve function defect in stroke patients. The placebo control method used in this study shows good clinical operability and masking effect.
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Humans , Acupuncture Therapy/methods , Acupuncture Points , Stroke/therapy , Lower Extremity , Needles , Treatment Outcome , Stroke RehabilitationABSTRACT
Objective:To evaluate the clinical efficacy of Sanjiao Cidi therapy on acute cerebral infarction and its effect on levels of S100-β protein （S100-β）， tumor necrosis factor-α （TNF-α）， hypersensitive C-reactive protein （hs-CRP） and neuropeptide （NPY）. Method:One hundred and eighty patients were randomly divided into control group （90 cases） and observation group （90 cases） by random number table. Patients in control group got aspirin enteric-coated tablets， 100 mg/time， 1 time/day， edaravone injection （injected within 30 minutes） for 14 days， 30 mg/time， 2 times/day， simvastatin tablets， 20 mg/time， 1 time/day. In addition to the basic therapy of meloxicam tablets， patients in observation group were also treated with Sanjiao Cidi therapy. In the first step， patients got Guizhi therapy to dredge Zhongjiao and Shangjiao， 1 dose/day， for 8 days. In the second step， patients got Sini therapy to dredge Zhongjiao and Xiajiao， 1 dose/day， for 10 days. In the third step， patients got Tianjing Gubentherapy， 1 dose/day， for 10 days. The course of treatment was 4 weeks. Before the treatment， and at the first， second， third and fourth weeks after treatment， National Institutes of Health Stroke Scale （NIHSS） was scored. And before and after treatment， function scale of fuglmeyer （FMA）， ability of daily life activities （ADL）， mini-mental state examination （MMSE） and main symptoms of traditional Chinese medicine were scored. Comprehensive assessment of patient report outcome （PRO） was made. And levels of S100-β， hs-CRP， TNF-α and NPY were detected. And the incidence rate of pulmonary infection， urinary infection， skeletal myalgia， shoulder hand syndrome and shoulder subluxation of patients were recorded during hospitalization. Result:The clinical efficacy in observation group was better than that in control group （Z=2.141， P<0.05）. Scores of NIHSS in observation group were lower than those in control group at the first， second， third and fourth weeks after treatment （P<0.01）. Scores of upper limb， legs and the total scores from FMA were higher than those in control group （P<0.01）. Scores of the main symptoms of traditional Chinese medicine， symptoms， psychological and social scores， total scores of PRO， S100-β， hs-CRP， TNF-α and NPY were lower than those in the observation group （P<0.01）. And scores of ADL and MMSE were higher than those in control group （P<0.01）. Total incidence of complications in observation group was 27.27%（21/77）， which was lower than 46.15%（36/78） in control group （χ2=5.941， P<0.05）. Conclusion:In addition to conventional western medicine treatment， Sanjiao Cidi therapy can treat the patients with acute cerebral infarction， alleviate the degree of neurological deficit， improve the cognitive function， motor function of limbs and the ability of daily life， reduce the main symptoms of traditional Chinese medicine， the incidence of complications and the inflammatory response， protect the nerve cells， with a better clinical efficacy and comprehensive effect in patients than pure Western medicine.
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Objective To observe the therapeutic effect of Qizhi Tongluo capsule on patients with apoplexy sequelae accompanied by qi deficiency and blood stasis. Methods Seventy-four patients with apoplexy sequelae accompanied by qi deficiency and blood stasis syndrome admitted to the Department of Traditional Chinese Medicine of Guangxi Zhuang Autonomous Region National Hospital From October 2014 to October 2017 were enrolled, they were randomly divided into a control group (36 cases) and an observation group (38 cases). Both groups were treated with acupuncture and moxibustion, intravenous drip of Xuesaitong and kept on a diet light, in control group, additionally Buyang Huanwu decoction (the ingredients: astragalus 50 g, angelica sinensis 12 g, allolobophora caliginosa trapezoides 10 g, peach kernel 10 g, szechwan lovage Rhizome 10 g, safflower 8 g, radix paeoniae rubra 10 g) was given, 1 dose daily, 1/2 dose being orally taken in the morning and 1/2 dose in the evening for consecutive 2 months: in the observation group, Qizhi Tongluo capsule 2 g was added, 2 times a day for consecutive 2 months. The differences in nerve function deficit score (NDS), the levels of triglyceride (TG) and cholesterol levels between the two groups were compared, and clinical therapeutic effects of two groups were observed. Results There were no statistical significant differences in NDS score (26.2±3.5 vs. 26.5±3.4), TG (mmol/L: 3.7±0.4 vs. 3.8±0.3), cholesterol (mmol/L: 7.5±1.3 vs. 7.3±1.2) before treatment in both groups (all P > 0.05), after treatment, the above indexes were significantly lowered than those before treatment, and the degrees of decrease after treatment in the observation group were more significant than those in the control group [NDS score: 12.6±2.8 vs. 20.7±2.8, TG (mmol/L): 1.1±0.2 vs. 1.9±0.3, cholesterol (mmol/L):4.8±1.2 vs. 5.7±1.1, all P < 0.05]; the total therapeutic effective rate in the observation group was significantly higher than that in the control group [94.7% (36/38) vs. 80.6% (29/36), P < 0.05]. Conclusion Qizhi Tongluo capsule can improve the clinical efficacy and effectively reduce the degree of nerve function defect in patients with apoplectic sequelae accompanied by qi deficiency and blood stasis syndrome.
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Objective To observe the effect of sequential therapy of butylphthalide injection and soft capsules for acute cerebral infarction and its influence on plasma lipoprotein phospholipase A2.Methods 120 patients with cerebral infarction were selected in the study,and they were divided into observation group (64 cases) and control group(56 cases) according to the digital table.The control group received conventional therapy plus placebo,the observation group received the sequential administration of butylphthalide injection and butylphthalide soft capsule treatment based on the conventional treatment.Before and after treatment,the plasma lipoprotein phospholipase A2 of the two groups was detected,and the National Institutes of Health Stroke Scale (NIHSS) was evaluated,compared neurological deficit improvement between the two groups and recorded adverse drug reactions of the two groups.Results There were no significant differences in NIHSS score and plasma lipoprotein phospholipase A2 level between the two groups before treatment(all P ＞ 0.05).After treatment,the NIHSS score of neurological impairment,plasma lipoprotein phospholipase A2 level in the observation group were (6.40 ± 5.22) points,(203.26 ± 29.33) ng/mL,those in the control group were (8.59 ± 6.22) points,(253.10 ± 52.99) ng/mL,the differences were statistically significant(t =-1.36,-2.089,P =0.039,0.000).The total effective rate of the observation group was 90.6％,which was higher than 67.9％ of the control group,the difference was statistically significant (x2 =9.676,P =0.002).The incidence rate of adverse reactions was similar in the two groups (P ＞ 0.05).Conclusion Sequential therapy of butylphthalide for acute cerebral infarction can improve the neurological function,decrease the level of plasma lipoprotein phospholipase A2,inhibit the inflammation of blood vessels,improve the prognosis of patients.
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Objective To investigate the effect of calf serum therapy on patients with cerebral hemorrhage in patients with neurological impairment and rehabilitation.Methods 110 cases of cerebral hemorrhage patients from August 2014 to April 2016 in our hospital,were randomly divided into study group and control group using SAS10.0 software,each has 55 cases,two groups were given routine treatment measures of oxygen,dehydration,blood pressure,the study group also received deproteinized calf serum injection treatment,observe the clinical effect of two groups of the patients.Results Before treatment,the two groups had no statistical significance in patients with NIHSS score,BI index difference,for 14 days and 1 months after treatment,the study group of patients with NIHSS score were lower than the control group(P<0.05),the study group of patients with BI score were higher than the control group(P<0.05); the 14 day after treatment.Two groups of patients with cerebral edema were treated for 3 days were significantly reduced(P<0.05); after 3 months of treatment,the basic cure rate of group 58.18％,significant improvement rate was 27.27％,the control group were 40％,significant progress was 34.55％,compared the two groups,the study group than the control group(P<0.05).Conclusion The use of calf serum therapy in patients with cerebral hemorrhage is helpful to the recovery of neurological function and activity of daily living.